منابع مشابه
De-Escalating Anti-Pseudomonal β-Lactams
Methods We retrospectively included all ICU episodes in Ghent University Hospital during 2013 and 2014 with prescription of meropenem, piperacillin-tazobactam or ceftazidime for at least 48 hours, stratifying between ICU episodes of < and ≥4 days; for outcome analysis, only the first ≥4 days episode per patient was included. Deescalation was defined as a change from meropenem to a non-carbapene...
متن کاملHigh Serum β-Lactams Specific/Total IgE Ratio Is Associated with Immediate Reactions to β-Lactams Antibiotics
Total serum IgE result from the combination of specific and non-specific pools. High specific/total IgE ratio may reflect high level of allergen-specific IgE on mast cells. No data regarding its applications to drug allergies is available. One hundred seventy-one patients with a history of immediate reactions to β-lactams, confirmed by positive skin testing, and 122 control subjects tolerant to...
متن کاملPharmacodynamic optimization of β-lactams in the patient care setting
In order to eradicate an infecting organism, it is necessary to achieve or maintain concentrations of an antibiotic in vivo that exceed the minimum inhibitory concentration (MIC) for the organism. Duration of exposure, or time above MIC, was recognized as being important for beta-lactam antibiotics more than 60 years ago. Continuous infusion regimens are associated with higher clinical response...
متن کاملReplicon Typing of Plasmids Encoding Resistance to Newer β-Lactams
Polymerase chain reaction-based replicon typing represents a novel method to describe the dissemination and follow the evolution of resistance plasmids. We used this approach to study 26 epidemiologically unrelated Enterobacteriaceae and demonstrate the dominance of incompatibility (Inc) A/C or Inc N-related plasmids carrying some emerging resistance determinants to extended-spectrum cephalospo...
متن کاملAccuracy in diagnosis of allergy to β-lactams
Critical Care [1]. In the issue of pharmacodynamics of β-lactams we missed a particular subject: allergy, subtle but sometimes important in intensive and critical care units since clinicians usually manage patients labelled as 'allergic' without having been studied and based only on clinical history [2]. Th is creates a health resource problem and leads to use alternative treatments in most cas...
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ژورنال
عنوان ژورنال: Reviews in Medical Microbiology
سال: 2013
ISSN: 0954-139X
DOI: 10.1097/mrm.0b013e3283587727